Fig. 5. Multiple mobilization events of an ARG may result in association with different mobile contexts.
Multiple contexts for ARGs of the same family as a consequence of multiple independent mobilization events on the example of blaPER ESBLs, mobilized from Pararheinheimera spp. Elliptic shapes (grossly) represent the areas from which different blaPER variants have been reported. Although blaPER-2 and blaPER-1 are both associated with ISPa12, the blaPER loci (including blaPER and co-mobilized genes) on the depicted MGEs are about 20% dissimilar in nucleotide identities. blaPER-6 is 13% dissimilar to blaPER-2 and about 20% dissimilar to blaPER-1. Transposable elements are presented with dotted pattern and blaPER genes with striped pattern.