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. 2021 Jan 4;12:28. doi: 10.1038/s41467-020-20194-0

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 9 — a To gain access to the nucleus, SOX2 binds IMPα3 with the NLS regions in an extended conformation to form a single interface. b When localized to the nucleus, these regions adopt a closed conformation for optimal DNA binding³⁶. c The regions are mutually exclusive and may suggest a possible release mechanism.