Fig. 5. Changes in gut viral communities in GvHD patient after FMTs.

a Proportion of viral taxa derived from donors in total taxa in patient’s stool samples. The proportion was calculated by using the method of fast expectation-maximization microbial source tracking (FEAST). One biological sample was examined over one experiment. b Relative abundances of eukaryotic and prokaryotic viruses in the donor and patient fecal samples. One biological sample was examined over one experiment. c Changes in relative abundance of a Torque teno virus in the patient. One biological sample was examined over one experiment. d Richness, Shannon and Simpson diversity of phages in donor and patient stools. e Relative abundances of Microviridae and Caudovirales phages in donor and patient stools. f Heatmap summarizing chronological alterations of 50 most dominant eukaryotic viral species in the patient’s viral community following FMTs at the species level. One biologically independent sample examined over one independent experiment. g Heatmap summarizing chronological alterations of 50 most dominant prokaryotic viral species in the patient’s viral community following FMTs at the species level. The abundance of selected species in a given sample is color-intensified according to the row z-score value, as indicated in the color bar. Blue to red color shades indicate increasing relative abundances.