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. 2021 Jan 4;12:56. doi: 10.1038/s41467-020-20255-4

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — a Images showing H&E, BrdU incorporation and Cleaved caspase-3 IHC in Vil-CreER^T2 (wild-type), Vil-CreER^T2 Rac1^fl/fl (Rac1^fl/fl) mice day 3 post induction and Vil-CreER^T2 Rac1^fl/fl (Rac1^fl/fl) mice 3 and 5 days post induction. Red arrow indicates disintegrating villus. Scale bar represents 100 μm in each case (See amplified images in Supplementary Fig. 1d–f). b Scanning EM on Vil-CreER^T2 (Wild-type) or Vil-CreER^T2 Rac1^fl/fl (Rac1^fl/fl) intestines 4 days post induction. Red arrows indicate rounded, blebbing cells. Scale bar represents 100 μm in the upper panels and 50 μm in the lower panels. c Vil-CreER^T2 driving expression of LifeAct-GFP in wild-type and Rac1^fl/fl intestines 4 days post induction. Scale bar represents 50 μm.