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. 2021 Jan 4;12:56. doi: 10.1038/s41467-020-20255-4

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — a Heatmap derived from RNA-seq analysis comparing whole tissue from wild-type (Vil-CreER^T2) and APC intestines (Vil-CreER^T2 Apc^fl/fl) n = 3 biologically independent animals for both APC and WT intestinal tissue. Log₂FC of GEF expression displayed on the right, genes significantly deregulated displayed in bold (FDR < 0.05) displayed in bold. b RNAscope of Vav2 in the intestinal epithelium of Vil-CreER^T2 Apc^fl/fl (APC) and Vil-CreER^T2 Apc^fl/fl, Vav3^−/− (APC V3) mice, Scale bar represents 100 μm. c Quantification of Vav2 RNAscope from Vil-CreER^T2 Apc^fl/fl and Vil-CreER^T2 Apc^fl/fl Vav3^−/− intestines. N = 5 biologically independent animals for each genotype. P = 0.0079 as determined by a two-tailed Mann–Whitney test. Data are presented as mean values ±SD.