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. 2021 Jan 4;12:22. doi: 10.1038/s41467-020-20294-x

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — a A cluster of 252 undifferentiated cell lines within the global Celligner-alignment. b Composition of the cell lines within the cluster (n = 252 cell lines). c Skin cell lines within the cluster do not express and do not depend on SOX10. d Liver cell lines within the cluster have lower expression of, and weaker dependency on, HNF4A. e Differential expression analysis shows an up-regulated mesenchymal profile and f enrichment of the EMT pathway for cell lines in the cluster. P-values are based on a gene-permutation test and adjusted using the Benjamini-Hochberg procedure (Methods, ‘Gene set enrichment analysis’). g Differential drug vulnerability analysis shows decreased sensitivity to EGFR inhibitors and increased sensitivity to tubulin polymerization inhibitors for cell lines in the cluster. h Differential dependency analysis shows stronger integrin-related dependencies for cell lines within the cluster.