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. 2021 Jan 4;4:13. doi: 10.1038/s42003-020-01551-7

Fig. 1. The number and cytokine-producing activity of skin T cells are maintained in elderly individuals.

Fig. 1

a Representative immunofluorescence (CD3)/immunohistochemistry (CD4, CD8) and CD3+, CD4+, and CD8+ numbers per field (Japanese). In the top immunofluorescence pictures, CD3 (red) and cytokeratin 5/6 (CK5/6, green) are co-stained. Epidermal CD3+ cells are indicated by white arrows. N = 9. Bar = 50 μm. b CD4/CD8 ratio in epidermis and dermis (Swedish). N = 20. c CD69/CD103 expression in skin CD8+ and CD49a expression in CD69+CD103+CD8+ (Swedish). N = 20. d Cytokine production of freshly isolated epidermal T cells, dermal T cells (Swedish), and whole-skin T cells under IL-2/IL-15 (Japanese). Epidermis and dermis (Swedish): IFNγ and IL-17A: n = 18, and TNF: n = 16; whole skin (Japanese): IFNγ: n = 18, IL-17A: n = 21, and TNF: n = 16. Spearman rank correlation coefficient (two-tailed) was performed in each graph. NS not significant, *p < 0.05, **p < 0.01.