Fig. 3. T cells from the skin but not blood maintain diversity in older individuals.

a Reperesentative TCRβ repertoires and scatterplots of clone occupancy in the blood and skin. b Number of unique clones. c Pielou’s evenness index (a higher index score means greater diversity). d Ratio of single-copy clones in the total unique clones. e Mean occupancy of the frequent clones. The cohort was divided into three groups according to age. Samples are from Japanese individuals. N = 16. Spearman rank correlation coefficient (two-tailed) was performed in (b–d). Two-way ANOVA and Tukey multiple-comparisons tests were applied to (e). NS not significant, *p < 0.05, **p < 0.01.