Table 2.

General characteristics for each step of the dosimetry workflow in the currently used dosimetry “Dosimetry Toolkit + OLINDA” software (the reference in this study), and the new PLANET® Dose package

	Dosimetry Toolkit® + OLINDA/EXM® V1.0	PLANET® Dose
Calibration procedure	GE recommendations: planar acquisitions Calibration factor: counts.s−1.MBq−1	No manufacturer’s recommendations Calibration factor: Bq.Count−1
Clinical imaging expected	Whole body scans, SPECT/CT or hybrid 5 time points maximum Only from GE devices	SPECT/CT or hybrid Unlimited time points Import in DICOM format from all devices
Reconstruction	« Preparation for Dosimetry Toolkit» application	Non applicable
Registration	« Preparation for Dosimetry Toolkit» application Automatic rigid registration between CT images (Full FOV)	Rigid or elastic registration Using CT data
Segmentation and propagation	Manual, semi-automatic or automatic segmentation using the first images (NM or CT) Rigid propagation (constant volumes) Segmentation adjusted by translation or rotation on others CT images	Manual, semi-automatic or automatic segmentation using the first images (NM or CT) Rigid propagation (constant volumes) No adjustment on others CT images
TIA fitting	Mono-exponential exclusively	Mono-exponential, Bi-exponential, Xexp, Trapezoidal, Tri-exponential, …
Absorbed dose calculation	Not avalaible on Dosimetry Toolkit® TIAC exported to OLINDA/EXM® V1.0	Local Deposition Method (LDM) Dose Kernel (DK) approach with / without density correction
Import/export	Not applicable	DICOM format (DICOM-RT-Structure and RT-Dose)

GE, general electric; FOV, field of view; NM, nuclear medicine; CT, computed tomography; TIA, Time tntegrated activity; TIAC, time integrated activity coefficient; DICOM-RT, digital imaging and communications in medicine-radiotherapy