. 2021 Jan 4;11:1. doi: 10.1186/s13550-020-00737-8

Table 3.

Dosimetry workflow in patients using the reference dosimetry approach Dosimetry Toolkit + OLINDA and the new workstation PLANET® Dose

	Dosimetry Toolkit® + OLINDA/EXM® V1.0	PLANET® Dose
Calibration procedure	SPECT/CT acquisitions Calibration factor (counts.s⁻¹.MBq⁻¹)	SPECT/CT acquisitions Calibration factor (Bq.Count⁻¹)
Clinical imaging	4 SPECT/CT at 4 h, 24 h, 72 h and 192 h after injection—60 projections of 45 s
Reconstruction	« Preparation for Dosimetry Toolkit» 6 iterations 10 subsets-AC, SC, RR, Gaussian post filter 0.11 cm
Registration	« Preparation for Dosimetry Toolkit» application Automatic rigid registration using CT images (Full FOV)	Organ-based rigid registration using CT images
Segmentation and propagation	Manual segmentation using the first CT image Rigid propagation (constant volumes) Segmentation adjusted by translation or rotation for other images	Manual segmentation using the first CT image Rigid propagation (constant volumes) No adjustment for other images
TIA fitting	Mono-exponential	Mono-exponential
Absorbed dose calculation	OLINDA/EXM® V1.0 Patient-adapted organ masses	Local Deposition Method (LDM) Dose Kernel (DK) approach with/without density correction

AC, attenuation correction; SC, scatter correction, RR, recovery resolution; FOV, field of view; CT, computed tomography; TIA, time integrated activity