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. 2020 Dec 1;124(1):207–216. doi: 10.1038/s41416-020-01173-0

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — a Anatomical T_2w images of TUBO, BALB-neuT, 4T1 and TS/A representative tumours. b Representative tumour extracellular pH maps for TUBO, BALB-neuT, 4T1 and TS/A tumours. c pH frequency distribution of TUBO, BALB-neuT, 4T1 and TS/A representative tumours. For TUBO, BALB-neuT and 4T1, the distribution was calculated as the mean frequency distribution in the two tumours. d Corresponding acidity score maps (colour-coded as red for pixels showing pH values <6.7; green for pH values >6.7 and <7; blue for pH values >7.0) superimposed on anatomical images. Tumour pHe and acidity score values are shown only within tumour regions for improving clarity.