Fig. 3. Single-cell network inference reveals candidate differential expression of transcription factors among major cell types.

a–c Representative upregulated TFs in the POP samples, which regulate ECM regulation and immune modulation and so on in fibroblasts (a), smooth muscle cells (b) and macrophages (c), respectively. The networks consist of several transcriptional factors and their target genes, color-coded by representative GO enrichment terms. The terms were listed on the right. The red square nodes represent TFs, and the round nodes represent target genes. Heatmaps of TFs and target genes expression were also shown on the left or the top. Con control, POP pelvic organ prolapse, TF transcription factors.