Table 3.
Intrinsic subtypes distribution in HER2-low tumors according to ERBB2 mRNA levels.
| Intrinsic subtype | ERBB2 high (T3-T2) | ERBB2 low (T1) | HER2-low | pa | pb | pc | |||
|---|---|---|---|---|---|---|---|---|---|
| N | % | N | % | N | % | ||||
| Luminal A | 140 | 51.5 | 44 | 31.7 | 184 | 44.8 | <0.001 | <0.001 | <0.001 |
| Luminal B | 95 | 34.9 | 22 | 15.8 | 117 | 28.5 | |||
| HER2-enriched | 17 | 6.3 | 5 | 3.6 | 22 | 5.4 | |||
| Basal-like | 8 | 2.9 | 62 | 44.6 | 70 | 17.0 | |||
| Normal-like | 12 | 4.4 | 6 | 4.3 | 18 | 4.4 | |||
| Total | 272 | 66.2 | 139 | 33.8 | 411 | 100.0 | |||
ERBB2 is italicized, as per standard gene ID formatting guidelines. T1: tertile one; T2: tertile two; T3: tertile 3.
aReferred to the comparison between ERBB2 high vs. low.
bReferred to ERBB2 high vs. the overall HER2-low population.
cReferred to ERBB2 low vs. the overall HER2-low population.