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. 2020 Nov 26;124(1):270–280. doi: 10.1038/s41416-020-01148-1

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — a Hierarchical clustering of genes that were significantly and differentially expressed in SW480-shCDX2 and the control cells. Data were log2 normalised. b Visualisation of differentially expressed genes for cellular conjunctions, focal adhesion, cytoskeleton and extracellular matrix of Gene Ontology Enrichment analysis in SW480-shCDX2 and the control cells. c, d Real-time PCR results of EMT-related genes in CDX2-knockdown (c) and CDX2-overexpressing (d) cells. e, f Western blotting bands for EMT-related proteins in CDX2-knockdown (e) and CDX2-overexpressing (f) cells. All data are presented as the mean ± SD from three independent experiments. *P < 0.05.