Fig. 2.

(A) HHV-6B subtree consisting of 72 circulating HHV-6B and 137 iciHHV-6B sequences. Gray numbers at each node represent posterior probabilities, showing only those with >0.80. Green labels represent endogenous iciHHV-6, whereas blue labels represent circulating infectious viruses. Collapsed nodes are represented as triangles for clarity (expanded in fig. 3). Collapsed nodes are labeled either green, blue, or both depending on whether the clade consists entirely of iciHHV-6B, HHV-6B, or a mixture of both. Where available, confirmation of the chromosomal location of iciHHV-6 is indicated with red labels. Gray text at each tip describes the geographical source of the sequence as well as the ethnicity of the patient where this information was available. Black labels indicate known reference strains of HHV-6B. (B) HHV-6 Bayesian phylogenetic tree reconstructed using 261 HHV-6 and iciHHV-6 sequences.