. 2020 Jan 29;15(1):147–159. doi: 10.1177/1932296819900258

Table 1.

Storage Recommendations for Different Insulin Products in the United States and European Union With the Shelf Life In-Use and the Maximum Temperature In-Use.

Type	Active substance	Manufacturer	Brand name	Region	Year first approval	Packaging	Shelf life in-use	Max. temperature in-use
Intermediate acting (NPH)	Isophane insulin	Eli Lilly	Humulin N	United States	1982	Prefilled pen	14 days	30°C
		Eli Lilly	Humulin N	United States	1982	Vial	31 days	30°C
		Novo Nordisk	Novolin N	United States	1991	Prefilled pen	28 days	30°C
		Novo Nordisk	Novolin N	United States	1991	Vial	42 days	25°C
		Sanofi	Insuman Basal	EU	1997	Pen cartridge	4 weeks	25°C
						Prefilled pen	4 weeks	25°C
						Vial	4 weeks	25°C
Long acting	Insulin degludec	Novo Nordisk	Tresiba	EU	2013	Pen cartridge	8 weeks	30°C
				EU	2013	Prefilled pen	8 weeks	30°C
				United States	2015	Prefilled pen	8 weeks	30°C
				United States	2015	Vial	8 weeks	30°C
	Insulin detemir	Novo Nordisk	Levemir	EU	2004	Pen cartridge	6 weeks	30°C
				EU	2004	Prefilled pen	6 weeks	30°C
				United States	2005	Prefilled pen	42 days	30°C
				United States	2005	Vial	42 days	30°C
	Insulin glargine	Eli Lilly	Abasaglar	EU	2015	Pen cartridge	28 days	30°C
			Abasaglar	EU	2015	Prefilled pen	28 days	30°C
			Basaglar	United States	2015	Prefilled pen	28 days	30°C
		Mylan	Semglee	EU	2018	Prefilled pen	4 weeks	30°C
		Sanofi	Lantus	EU	2000	Prefilled pen	28 days	30°C
				EU	2000	Vial 10 mL	28 days	30°C
				United States	2000	Prefilled pen	28 days	30°C
				United States	2000	Vial 10 mL	28 days	30°C
			Toujeo	EU	2015	Prefilled pen	6 weeks	30°C
			Toujeo	United States	2015	Prefilled pen	56 days	30°C
Long acting + glp-1 agonist	Insulin degludec + liraglutide	Novo Nordisk	Xultophy	EU	2014	Prefilled pen	21 days	30°C
	Insulin degludec + liraglutide	Novo Nordisk	Xultophy	United States	2016	Prefilled pen	21 days	30°C
	Insulin glargine + lixisenatide	Sanofi	Soliqua	United States	2016	Prefilled pen	28 days	25°C
	Insulin glargine + lixisenatide	Sanofi	Suliqua	EU	2017	Prefilled pen	28 days	25°C
Premixed	Human insulin + human insulin isophane	Eli Lilly	Humulin 70/30	United States	1989	Prefilled pen	10 days	30°C
		Eli Lilly	Humulin 70/30	United States	1989	Vial	31 days	30°C
		Novo Nordisk	Actraphane	EU	2002	Pen cartridge	6 weeks	30°C
						Prefilled pen	6 weeks	30°C
						Vial	6 weeks	25°C
			Insulatard	EU	2002	Pen cartridge	6 weeks	30°C
						Prefilled pen	6 weeks	30°C
						Vial	4 weeks	25°C
			Mixtard	EU	2002	Pen cartridge	6 weeks	30°C
						Prefilled pen	6 weeks	30°C
						Vial	6 weeks	25°C
			Novolin 70/30	United States	1991	Prefilled pen	28 days	30°C
			Novolin 70/30	United States	1991	Vial	42 days	25°C
			Protaphane	EU	2002	Pen cartridge	6 weeks	30°C
						Prefilled pen	6 weeks	30°C
						Vial	4 weeks	25°C
		Sanofi	Insuman Comb	EU	1997	Pen cartridge	4 weeks	25°C
						Prefilled pen	4 weeks	25°C
						Vial	4 weeks	25°C
	Insulin aspart + protamine-crystallized insulin aspart	Novo Nordisk	NovoLog Mix 70/30	United States	2001	Prefilled pen	14 days	30°C
			NovoLog Mix 70/30	United States	2001	Vial	28 days	30°C
			NovoMix	EU	2000	Pen cartridge	4 weeks	30°C
			NovoMix	EU	2000	Prefilled pen	4 weeks	30°C
	Insulin degludec/insulin aspart	Novo Nordisk	Ryzodeg	EU	2013	Pen cartridge	4 weeks	30°C
			Ryzodeg	EU	2013	Prefilled pen	4 weeks	30°C
			Ryzodeg 70/30	United States	2015	Prefilled pen	28 days	30°C
	Insulin lispro + insulin lispro protamine	Eli Lilly	Humalog Mix	United States	1999	Prefilled pen	10 days	30°C
	Insulin lispro + insulin lispro protamine	Eli Lilly	Humalog Mix	United States	1999	Vial	28 days	30°C
Rapid acting	Human insulin	MannKind	Afrezza	United States	2014	Inhaler cartridge	10 days	30°C
	Insulin aspart	Novo Nordisk	Fiasp	EU	2017	Pen cartridge	4 weeks	30°C
						Prefilled pen	4 weeks	30°C
						Vial	4 weeks	30°C
				United States	2017	Prefilled pen	28 days	30°C
				United States	2017	Vial	28 days	30°C
			NovoLog	United States	2000	Pen cartridge	28 days	30°C
						Prefilled pen	28 days	30°C
						Vial	28 days	30°C
			NovoRapid	EU	1999	Pen cartridge	4 weeks	30°C
						Prefilled pen	4 weeks	30°C
						Pump cartridge	in use: 7 days	30°C
						Vial	4 weeks	30°C
	Insulin glulisine	Sanofi	Apidra	EU	2004	Pen cartridge	4 weeks	25°C
						Prefilled pen	4 weeks	25°C
						Vial	4 weeks	25°C
				United States	2004	Prefilled pen	28 days	25°C
						Vial	28 days	25°C
						Vial (use in pump)	2 days	37°C
	Insulin lispro	Eli Lilly	Humalog	EU	1996	Pen cartridge	28 days	30°C
						Prefilled pen	28 days	30°C
						Vial	28 days	30°C
				United States	1996	Pen cartridge	28 days	30°C
						Prefilled pen	28 days	30°C
						Vial	28 days	30°C
			Liprolog	EU	2001	Pen cartridge	28 days	30°C
						Prefilled pen	28 days	30°C
						Vial	28 days	30°C
		Sanofi	Admelog	United States	2017	Prefilled pen	28 days	30°C
			Admelog	United States	2017	Vial	28 days	30°C
			Insulin lispro Sanofi	EU	2017	Pen cartridge	4 weeks	30°C
						Prefilled pen	4 weeks	30°C
						Vial	4 weeks	30°C
Short acting/regular	Human insulin	Eli Lilly	Humulin R	United States	1982	Vial	31 days	30°C
			Humulin R U-500	United States	1994	Prefilled pen	28 days	30°C
			Humulin R U-500	United States	1994	Vial	40 days	30°C
		Novo Nordisk	Actrapid	EU	2002	Pen cartridge	6 weeks	30°C
						Prefilled pen	6 weeks	30°C
						Vial (40 U/mL)	4 weeks	25°C
						Vial (100 U/mL)	6 weeks	25°C
			Novolin R	United States	1991	Prefilled pen	28 days	30°C
			Novolin R	United States	1991	Vial	42 days	25°C
		Sanofi	Insuman Implantable	EU	1997	Vial	45 days	37°C
			Insuman Infusat	EU	1997	Pump cartridge	2 weeks	na
			Insuman Infusat	EU	1997	Vial	2 weeks	25°C
			Insuman Rapid	EU	1997	Prefilled pen	4 weeks	25°C
			Insuman Rapid	EU	1997	Vial	4 weeks	25°C

Abbreviation: NPH, neutral protein Hagedorn.

Source: Information taken from the Summary of Product Characteristics (SmPC) from FDA and European Assessment Reports (EPAR) from EMA.¹⁹