Table 1.
Demographics and neuropsychological profile (participant and comparison groups).
| Participant n = 1 | A–/T– HCn = 99 | A+/T+ MCI n = 16 | A+/T+ ADn = 21 | |
|---|---|---|---|---|
| Age | ||||
| Median (IQR)a | 63 | 72.6 (70.4–75.4) | 72.8 (69.0–76.4) | 73.7 (66.0–77.6) |
| Sex | ||||
| Male, n (%) | Male | 47 (47.5%) | 11 (68.8%) | 11 (52.4%) |
| MMSE | ||||
| Median (IQR) | 29 | 29 (28–30) | 26 (23–28) | 23 (17–25) |
| CDR | ||||
| Mean (SD) | 0.5 | 0.04 (0.13) | 0.5 (0) | 0.88 (0.44) |
| Years of education | ||||
| Median (IQR) | 15 | 15 (12–16) | 11 (10–15) | 11 (10–15) |
| Centiloid value | ||||
| Median (IQR) | 51 | −0.6 (−3.5–3.6) | 128 (100–148) | 124 (96–141) |
| HADS-Db | ||||
| Median (IQR) | 7.0 | 1.0 (1.0–2.0) | 2.0 (1.0–3.3) | 2.5 (1.0–5.8) |
| HADS-Ac | ||||
| Median (IQR) | 6.0 | 3.0 (2.0–4.3) | 5.0 (4.0–7.0) | 4.0 (2.0–6.0) |
| Premorbid IQ | ||||
| Median (IQR) | 110 | 114 (109–117) | 109 (102–111) | 104 (101–112) |
| Neuropsychological measures (z-scores) | ||||
| Word list recalld | −2.27 | 1.13 (0.81) | −1.75 (0.82) | −2.18 (0.77) |
| RCFT copy score | −0.54 | -0.98 (1.09) | −2.76 (2.83) | −4.63 (6.52) |
| RCFT (3-min delayed recall) | −2.31 | 1.14 (1.45) | −1.70 (0.67) | −2.22 (1.04) |
| RCFT (30-min delayed recall) | −3.85 | 1.21 (1.56) | −1.79 (0.69) | −2.32 (1.19) |
| COWAT | −0.66 | 0.97 (1.09) | -0.19 (1.19) | −0.20 (1.10) |
| Trail Making Task B | −0.33 | – | – | – |
| Digit span | 0.33 | 0.64 (1.01) | 0.19 (1.09) | −0.44 (0.90) |
| Digit symbol coding | 0.66 | 0.92 (0.82) | −0.33 (0.79) | −0.96 (0.99) |
A–/T–, amyloid-β negative, tau negative; A+/T+, amyloid-β positive, tau positive; MMSE, Mini-Mental State Examination; CDR, Clinical Dementia Rating scale; HADS-D, Depression subscale of the Hospital Anxiety and Depression Scale; HADS-A, Anxiety subscale of the Hospital Anxiety and Depression Scale; RCFT, Rey Complex Figure Test; COWAT, Controlled Oral Word Association Test (component of the Delis-Kaplan Executive Function System verbal fluency test).
Mean (SD) for all neuropsychological z-scores.
The case participant was 63 years of age at the time of neuropsychological assessment, amyloid, and tau imaging.
HADS-D: raw score; 0–7 = low score (none–mild symptoms); 8–10 = moderate; 11–21 = high (21).
HADS-A: raw score; 0–7 = low score (none–mild symptoms); 8–10 = moderate; 11–21 = high (21).
Participant was administered the Rey Auditory Verbal Learning Test (RAVLT), while comparison groups were administered the California Verbal Learning Test (CVLT).