Table 2.
Effect of tadalafil loaded amorphous solid dispersion on the mount latency (ML), mount frequency (MF), intromission latency (IL), intromission frequency (IF), ejaculation latency (EL), Copulatory Efficiency (CE) and Intercopulatory Efficiency (IE) of male rats.
| Animal Groups | Sexual Behaviour Parameters |
||||||
|---|---|---|---|---|---|---|---|
| ML(sec) | MF | IL(sec) | IF | EL(sec) | CE(%) | IE(%) | |
| Group I- normal control | 90.1 ± 5.23 | 5.0 ± 0.32 | 289.7 ± 2.15 | 2.9 ± 0.19 | 275.6 ± 6.12 | 58.00 | 36.71 |
| Group II positive control | 61.0 ± 0.11ǂ | 9.2 ± 0.10ǂ | 89.1 ± 1.43ǂ | 6.1 ± 0.35ǂ | 382.1 ± 11.10ǂ | 66.30 | 39.87 |
| Group III Test-(ASD3) | 52.4 ± 2.50ǂ* | 10.2 ± 0.37ǂ* | 78.7 ± 4.73ǂ* | 7.7 ± 0.19ǂ* | 439.2 ± 17.20ǂ* | 75.49 | 43.02 |
Readings are listed as average ± S.E.M., n = 5 rats per group.
ǂ
Designate significance compared to Group I- normal control at p < 0.05.
*
Designate significance compared to Group II positive control at p < 0.05