. 2020 Nov 5;28(12):1686–1703. doi: 10.1016/j.jsps.2020.10.015

Table 2.

Isolated phytoconstituents of evaluated extracts from Millettia species.

Plant Species	Phytoconstituents	Chemical class	Extracts	References
M. extensa (Benth.) Baker	Millexatins A, Millexatins B, Millexatins C, Millexatins D, Millexatins E, Millexatins F, Auriculatin, Scandenone, Elongatin, Auriculasin, Isoauriculasin, isoauriculatin, 3′-methylorobol, 7,4′-di-O-prenylgenistein, 2′-deoxyisoauriculatin, 2′-O-methylisoauriculatin, 4′-methylalpinumisofiauone, 5-O-methyl-4′-O-(3-methyl-2-utenyl)alpinumisoflavone, 5-hydroxy-7-methoxy-4′-O-(3-methylbut-2-enyl) isoflavones	Isoflavones	Acetone	(Padhi et al., 2017, Raksat et al., 2018)
	(−)-maackiain	Pterocarpan
	(−)-sumatrol (−)-6a,12a-dehydrotoxicarol	Rotenoids
M. ovalifolia Kurz	7-(4 methoxyphenyl)-9H-furo[2,3-f]chromen-9-one,	Flavonoids	Chloroform fraction of methanol extract	(Rahman et al., 2015)
M. ovalifolia Kurz	Pervilleanone (Potent hypotensiveagent)	Prenylated isoflavanone		(Rahman et al., 2015)
M. pachycarpa Benth.	4-methoxylonchocarpin, dorspoinsettifolin, isobavachromene, deguelin, tephrosin, barbigerone, 4′,5′-dimethoxy-6,6-dimethylpyrano isoflavones, 4′-hydroxyisolonchocarpin, 12a-hydroxyrotennone	Flavonoids	EtOAc extract	(Tu et al., 2019, Su et al., 2012)
	3-hydroxy4-methoxylonchocarpin	Prenylated chalcone	Petroleum ether fraction of ethanol extract
	4-methoxylonchocarpin Isobarachromene Dorspoinsettifolin	Flavonoids	Petroleum ether fraction of ethanol extract
M. dielsiana Harms ex Diels	Mildiside-A	Isoflavonoe glycoside	Chloroform and EtOAc fraction of ethanol extract	(Dat et al., 2019)
M. dielsiana Harms ex Diels	Formononetin, ononin, isoliquiritigenin, liquiritigenin, naringenin, gallocatechin, catechin, (3S)-vestitol, tupichinol C, (+)-epicatechin, (−)-epicatechin, protocatechuic acid, trans-ferulic acid, trans-3-O-p-hydroxycinnamoyl ursolic acid	Phenolic derivatives	Chloroform and EtOAc fraction of ethanol extract	(Dat et al., 2019)
M. dura Dunn	3-O-prenylmaackiain	Pterocarpan	Chloroform: methanol(1:1)	(Marco et al., 2017)
	Calopogonium isoflavone B, Maximaisoflavone B, durmillone, isoerythrin A-4′-(3-methylbut-2-enyl) ether, 7-hydroxy-8,3′,4′-trimethoxyisoflavone, 7,2′-dimethoxy-4′,5′-methylenedioxyisoflavone	Isoflavones
	Butein	Chalcone
M. pervilleana	3-phenylcoumarin or pervilleanine	Prenylated isoflavanone	Chloroform	(Palazzino et al., 2003)
	Pervilline, Pervillinine	Pterocarpans
	3α-hydroxyrotenone	Rotenone
	Pervilleanone, 3′-O-demethylpervilleanone	Isoflavanones
M. griffoniana Baill.	4′-methoxy-7-O-[(E)-3-methyl-7-hydroxymethyl-2,6-octadienyl]isoflavone, 3′,4′-dihydroxy-7-O-[(E)-3,7-dimethyl-2,6-octadienyl]isoflavone,	O-geranylated isoflavones	n-hexane, chloroform	(Yankep et al., 1998)
M. griffoniana Baill.	4-hydroxy-5,6,7-trimethoxy-3-(3′,4′-methylenedioxy)phenylcoumarin	3-phenylcoumarin	n-hexane, chloroform	(Yankep et al., 1998)
M. erythrocalyx Gagnep.	6-methoxy-[2″,3″:7,8]-furanoflavanone, 2,5-dimethoxy-4-hydroxy-[2″,3″:7,8]-furanoflavan	Flavonoid	n-hexane, chloroform, methanol	(Sritularak and Likhitwitayawuid, 2006)
M. erythrocalyx Gagnep.	3,4-methylenedioxy-2′,4′-dimethoxychalcone	Chalcone	n-hexane, chloroform, methanol	(Sritularak and Likhitwitayawuid, 2006)
M. laurentii De Wild.	3′, 6 '-diketo-7-hydroxy-8,2′,4′-trimethoxyisoflavan or laurentiquinone	Isoflavan-quinone	n-hexane, chloroform, EtOAc, methanol	(Kamnaing et al., 1994, Kamnaing et al., 1999)
	3,7,4 '-trihydroxy-3′,5′-dimethoxyflavone or laurentinol	Flavonol
	Calycosin, Glyricidin	Isoflavones
M. oblate ssp. teitensis	4- prenyloxyderrone, durmilone, 8-O-methylretusin, Maximaisoflavone B, Maximaisoflavone H, Maximaisoflavone J	Isoflavone	CH₂Cl₂:MeOH (1:1)	(Derese et al., 2014)
	Tephrosin	Rotenoid
	Lupeol	Triterpene
M. leucantha Kurz	1-(3-hydroxy-4-methoxyphenyl)-3-(2,4-dihydroxy-5-methoxyphenyl)propan-1-ol (millettinol) physcion, (R)-(-)-mellein, isoliquiritigenin	Phenolic compound	n-BuOH, EtOAc fraction of ethanol extract	(Rayanil et al., 2011)
	4-hydroxy-3-methoxy-8,9-methylenedioxypterocarpan 3-hydroxy-9-methoxypterocarpan or medicarpin	Pterocarpan
	5,4′-dihydroxy-7,8-dimethoxyisoflavone	Isoflavone
M. pinnata (L.) Panigrahi	Resin, flavonoids, terpenoids, phenols, saponins, alkaloids, alkyd resin			(Bora et al., 2014)
M. pinnata (L.) Panigrahi	Palmitic acid, stearic acid, oleic acid, linoleic acid, lignoceric acid, arachidic acid and behenic acid	Fatty acid	Oil extract	(Bora et al., 2014)
M. speciosa Champ.	Naringenin, liquiritigenin, garbanzol	Flavonoid	n-BuOH, EtOAc fraction of ethanol extract	(Fu et al., 2016)
	Calycosin, 2′-hydrroxybiochanin 7-hydroxy-6,4′-dimethoxyisoflavone, 2′5′7-trihydroxy-4′-methoxyisoflavone, 6-methoxycalopogonium isoflavones A	Isoflavones
	Secoisolariciresinol, polystachyol	Lignan
	4,4′-dihydroxy-2′-methoxychalcone, 2,4′-dihydroxy-4-methoxychalcone	Chalcones
	Rhododendrol	Phenolic compound
	Polysaccharide(MSCP2)		Aqueous	(Huang et al., 2020)
M. brandisiana Kurz	Brandisianones A, Brandisianones B, Brandisianones C, Brandisianones D, Brandisianones E	Flavonoids	Dichloromethane	(Pailee et al., 2019)
M. conraui Harms	Conrauinones C, Conrauinones D, 7- hydroxyl-6-methoxy-3′,4′-methylenedioxy isoflavone	O-geranylated isoflavones	Benzene	(Fuendjiep et al., 1998)
M. duchesnei De Wild.	Elliptol, 12-deoxo-12-α-methoxyelliptone, 6-methoxy-6a,12a-dehydrodeguelin, 6a,12a-dehydrodeguelin, 6-hydroxy-6a,12a-dehydrodeguelin, 6-oxo-6a,12a-dehydrodeguelin, elliptone, 12a-hydroxyelliptone, eriodictyol	Prenylated rotenoids	CH₂Cl₂:MeOH (1:1)	(Ngandeu et al., 2008)
M. micans Taub.	Micanspterocarpan	Pterocarpan	CH₂Cl₂:MeOH (1:1)	(Marco et al., 2017)
M. griffithii Dunn	Griffinones A, Griffinones B, Griffinones C, Griffinones D, Griffinones E	Flavonoids	n-hexane, EtOAc	(Tang et al., 2016)
M. griffithii Dunn	Griffiliganan A	Biphenylneolignan	n-hexane, EtOAc	(Tang et al., 2016)
M. manni Baker	5-hydroxy-4,7′-dimethoxyisoflavone	Isoflavones	Methanol	(Kamto et al., 2012)
M. manni Baker	Furanonaphthoquinone	Naphthalene	Methanol	(Kamto et al., 2012)
M. pachyloba Drake	Pachyloisoflavone A, Pachyloisoflavone B	Prenylated isoflavones	Ethanol	(Na et al., 2017)
	Pachylobin A	Pterocarpan
	6-methoxycalogonium isoflavones A, durallone, genistein, millesianin C, millesianin D, afromosin, hernancorizin, ichthynone, 5-hydroxy-2′,4′,5′,7-tetramethoxyflavone	Flavonoids
M. pulchra Kurz	(2S)-5,7,4′-trihydroxy-8,3′,5′-triprenylflavanone, (2R,3R)-7,4′dihydroxy-8,3′,5′-triprenyldihydroflavanol, 5,7,2′,4′-tetrahydroxy-6,3′-diprenylisoflavone, 5,7,4′-trihydroxy-2′-methoxy-6,3′-diprenylisoflavone.	Isoflavones	Chloroform, methanol	(Baruah et al., 1984)
M. pulchra Kurz	(6S, 6aS, 11aR)-6a-methoxypterorpin, (6S, 6aS,l1aR)-6α-methoxyhomopterocarpin	Pterocarpan	Chloroform, methanol	(Baruah et al., 1984)
M. usaramensis Taub.	(6aR,12aS)-2,3-methylenedioxy-9-methoxy-8-(3,3-dimethylallyl)-12a-hydroxyrotenoid (usararotenoid C)	Rotenoids	Dichloromethane	(Yenesew et al., 2003)
M. usaramensis Taub.	12a-epimillettosin, 6a,12a-dehydromillettone, barbigerone, 4′-O-geranylisoliquiritigenin	Flavonoids	Dichloromethane	(Yenesew et al., 2003)
M. barteri (Benth.) Dunn	Millaurine, milletonine	Guanidine alkaloids	Methanol	(Havyarimana et al., 2012)
	Afzelin	Flavonoid
	β-sitosterol, β-sitosterol glucoside, a mixture of stigmasterol and β-sitosterol, palmitates	Sterols
M. peguensis Ali	Pentadecane, Tetradecane, Octadecane, Undecane, 9-methylheptadecane, Heptadecane, 2,6,10,15-tetramethyl- 2-Bromo dodecane	Alkane hydrocarbon	Petroleum ether	(Manikandan et al., 2017)
M. peguensis Ali	Eicosane, Heneicosane	Acyclic alkane	Petroleum ether	(Manikandan et al., 2017)