Table 2.
Particle size, polydispersity index, zeta potential and entrapment efficiency.
| Batches | Particle size (mean ± S.Da) (nm) | Polydispersity (mean ± S.Da) | Zeta potential (mean ± S.Da) (mV) | Entrapment efficiency (%) (mean ± S.Da) |
|---|---|---|---|---|
| Cfz | – | – | – | – |
| CS-NP | 126.7 ± 1.21 | 0.31 ± 0.030 | 13.05 ± 0.02 | – |
| Cfz-CS-NP | 132.8 ± 2.30 | 0.32 ± 0.013 | 12.05 ± 0.01 | 94.86 ± 0.55 |
| Cfz-CS-MNS-NP | 184.7 ± 2.37 | 0.33 ± 0.017 | 9.12 ± 0.08 | 73.45 ± 1.47 |
| CM6-CS-NP | 134.7 ± 0.55 | 0.23 ± 0.023 | 4.13 ± 0.05 | 92.88 ± 0.64 |
| CM6-CS-MNS-NP | 182.9 ± 0.73 | 0.26 ± 0.014 | 2.19 ± 0.12 | 87.27 ± 0.90 |
n = 3.
S.Da: Standard deviation.
Cfz: Clofazimine pure drug.
CS-NP: TPGS emulsified chitosan nanoparticles.
Cfz-CS-NP: Cfz loaded TPGS emulsified chitosan nanoparticles.
Cfz-CS-MNS-NP: Cfz loaded mannose receptor targeted nanoparticles.
CM6-CS-NP: CM6 loaded chitosan nanoparticles.
CM6-CS-MNS-NP: CM6 loaded mannose receptor targeted nanoparticles.