Table 1.

Epigenetic reader modules and the histone marks recognized

Modification	Residue	Family	Member
Acetylation	Lysine	BRD	BRD 2/3/4/T/7/9
Methylation	Lysine	CRDs	MORF, MRG15
		Tudor domains	MBT, PHF1/19, TDRD7
		PWWP domains	BRPF1, NSD1-3
		Ankyrin repeats	GLP/G9a
	Arginine	Tudor domains	WDR5, TDRD3, SMN1
Phosphorylation	Serine	14-3-3 proteins BRCT domain	14-3-3β/γ/η/ε/µ
	Threonine	BIR domain	XRCC1, NBS1, BARD1
	Tyrosine	PTB domain
Ubiquitination	Lysine		53BP1
ADP-ribosylation	Glutamate	Macrodomains	RNF146
	Arginine	PBZ	APLF, CHFR
	Glutamate	WWE domain

BRD, bromodomain; CRD, chromodomain; PWWP, Pro-Trp-Trp-Pro; MORF, monocytic leukemia zinc finger protein-related factor; MRG15, MORF4-related gene on chromosome 15; MBT, malignant brain tumor; PHF, plant homeodomain (PHD) finger; TDRD3/7, Tudor domain containing proteins 3 and 7; BRPF1, BRD and PHD finger-containing protein 1; NSD1-3, nuclear receptor binding SET domain proteins 1-3; GLP, G9a-like protein; WDR5, WD repeat domain 5; SMN1, survival of motor neuron 1; BRCT, BRCA1 C terminus; BIR, baculovirus IAP repeat; XRCC1, X-ray repair cross complementing 1; NBS1, Nijmegen breakage syndrome 1; BARD1, BRCA1 associated RING domain 1; PTB, phosphotyrosine-binding; 53BP1, tumor suppressor p53-binding protein 1; PBZ, PAR-binding zinc finger; WWE, Trp-Trp-Glu; RNF146, RING finger protein 146; APLF, aprataxin and PNKP like factor; CHFR, checkpoint with forkhead and RING finger domains (Adapted from Catia et al., 2019 [26]).