Table 2.

Natural compounds targeting epigenetic ‘reader’ domains

Name & structure		Origin	Target	Reference
Naringenin triacetate		Citrus aurantium (bitter orange)	BRD4	104
3-O-acetylpinobanksin		Black poplar tree
Kaempferol tetracetate		Cudrania tricuspidata (mandarin melonberry)
Resveratrol		Peanuts, berries, grape skin, apples	BRD4	112
Isoliquiritigenin		Glycyrrhiza glabra (licorice plant)	BRD4	113
Amentoflavone		Ginkgo biloba, Hypericum perforatum (St. John’s Wort), Biophytum sensitivum, Nandina domestica (sacred bamboo)	BRD4	102
Fisetin		Cucumber, onion, strawberry, apple
Aristoyagonine		Sarcocapnos enneaphylla	BRD4	125
α-Viniferin		Caragana sinica, camphor tree, Astilbe grandis	BRD4	134
Euscaphic acid		Plectranthus amboinicus (French thyme, Cuban oregano, Indian mint), Ziziphus jujuba (red date)
Magnolol		Magnolia tree	BRD9	135
Colchicine	Colchiceine	Colchicum speciosum (autumn crocus)	BRD4	126
Terrein		Mangrove-derived Streptomyces sp. SZ-A15	BRD4	136
4-oxo-Staurosporine		Marine-derived Streptomyces sp. NB-A22	BRD4	130
3,11α,12β,13β,6-pentahydroxy-11,12-dihydroperylen-6(13H)-one		Marine fungi: Alternaria sp. NH-F6	BRD4	137
5-hydroxymethyl-furan-2-carboxylic acid		Marine fungi: Phoma sp. CZD-F11, Aspergillus sp. CZD-F18	BRD4	138
4-hydroxymethyl catechol		Marine fungi: Phoma sp. CZD-F11, Aspergillus sp. CZD-F18
12-hydroxy-verruculogen TR-2	Fumitremorgin B	Penicillium sp. DT-F29 with Bacillus sp. B31	BRD4	131