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. 2020 Dec 22;8:615264. doi: 10.3389/fcell.2020.615264

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Copyright © 2020 Yahya, Morosan-Puopolo and Brand-Saberi.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Expression of CXCR4 and its ligand SDF-1 during head and neck muscle development. (A,B) Whole-mount in situ hybridization of CXCR4 (A) and SDF-1 (B) in mouse embryos at E12.5. Note labeling of BA2-derived muscles anlage (fr, bu, oo, zy, au, qua) by CXCR4. CXCR4 is also expressed in non-somitic neck muscles (a-trap, s-trap). SDF-1 is expressed in the adjacent mesenchyme of the face. (C,D) Whole-mount in situ hybridization of CXCR4 (A) and SDF-1 (B) in chicken embryos at HH22. CXCR4 and SDF-1 are expressed in complementary patterns in the chicken branchial arches. Black and red arrows mark CXCR4 and SDF-1 in the BAs. a-trap, acromio-trapezius; au, auricularis; BA1-2, branchial arches 1–2; bu, buccinator; fr, frontalis; oo, orbicularis oculi; ov, otic vesicle; qua, quadratus labii; s-trap, spino-trapezius; zy, zygomaticus.