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. 2020 Dec 22;8:615264. doi: 10.3389/fcell.2020.615264

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Copyright © 2020 Yahya, Morosan-Puopolo and Brand-Saberi.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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SDF-1 guides the migration of the second arch-derived muscle progenitor cells. To further test the role of CXCR4 in early head muscle development, we injected quail cells into the right side of the head mesoderm of recipient chicken embryos at HH11 (A) followed by AMD3100, SDF-1 or PBS beads implantation (B). The quail cells emigrated from the head mesoderm and populated BA2 of hosts. The quail cells were traced by whole-mount immunostaining for QCPN (C–E). Whole-mount immunostaining revealed that the positive quail cells were prevented from entering the BA2 in AMD3100 implanted embryos, but not PBS-treated embryos. In the case of SDF-1 treated embryos, the quail cells were expanded and attracted.