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Schematic diagram of the regulation of CRP1 on the dissimilatory nitrate reduction to ammonia and denitrification. The positive regulation of CRP1 on transcription of nap-α and nrfA is mediated by its direct binding to specific motifs at the promoter region, while the negative regulation on nirK, norBC, and nosZ may be exerted via another unknown regulator, probably another CRP paralogue, CRP2. The ultimate goal is to make the most of the limiting factor.
