Figure 1.

Schematic of the DMD gene. Shown is a genome browser visualization (www.genome.ucsc.edu), with labels added for the 6 different gene promoters, resulting mRNAs, and encoded proteins. Gene mutations in the first half of the gene may affect dystrophin expression driven from the first 3 promoters driving ‘full length’ dystrophin (Dp427B, Dp427M, Dp427P), but leave intact expression of downstream promoters (Dp71, Dp116, Dp140). Mutations located in the second half of the gene may disrupt expression or most or all dystrophin mRNAs and proteins driven from all promoters.