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L-citrulline pretreatment prevents high glucose-induced elevation in arginase activity in endothelial cells. Arginase activity in BAECs representing an average of three separate experiments done in triplicate. High glucose treatment caused a 50% increase in arginase activity. Pretreatment with L-citrulline (2.5 mM) inhibited the high glucose-induced increase in arginase activity. Statistical analysis performed using one-way ANOVA followed by Tukey’s post hoc test *p < 0.05.
