Table 3.
hCFR meta-estimates of human metapneumovirus-associated ALRI and in-hospital deaths in children younger than 5 years in 2018, by age group and by World Bank income levels and level of child mortality by setting (low vs high)
| LMICs | UMICs | HICs | Settings with low child mortality | Settings with high child mortality | Global estimates* | ||
|---|---|---|---|---|---|---|---|
| Studies, n | 15 | 6 | 7 | 7 | 21 | .. | |
| 0–5 months | |||||||
| hCFR, %† | 4·5% (2·3–8·6) | 1·7% (0·6–5·1) | 0·4% (0–8·6) | 0·4% (0–8·6) | 3·3% (1·7–6·1) | .. | |
| Deaths, n | 4300 (2000–9200) | 1000 (300–3700) | 100 (0–3400) | 200 (0–9900) | 4600 (2100–9900) | 4900 (2100–19 300) | |
| 6–11 months | |||||||
| hCFR, %† | 0·7% (0–9) | NA | 0·6% (0·1–3·9) | 0·6% (0·1–3·9) | 0·2% (0–7·6) | .. | |
| Deaths, n | 900 (0–37 800) | NA‡ | 100 (0–700) | 300 (0–1900) | 200 (0–9400) | 600 (100–11 300) | |
| 12–59 months | |||||||
| hCFR, %† | 0·9% (0·3–2·8) | 1·1% (0·1–9·1) | 0·5% (0–7·0) | 0·5% (0–7) | 0·9% (0·2–3·6) | .. | |
| Deaths, n | 1800 (500–6500) | 600 (100–6600) | 100 (0–2800) | 300 (0–10 100) | 1900 (400–8300) | 2200 (400–18 300) | |
| 0–59 months§ | |||||||
| Deaths, n | 7200 (2600–52 300) | 1700 (300–10 300) | 300 (0–6900) | 800 (100–22 200) | 6800 (2500–27 100) | 7700 (2600–48 800) | |
Data in parentheses are estimated uncertainty ranges. Settings in which the under-5 mortality rate was higher than the median under-5 mortality rate for 2018, were considered high child mortality settings, and settings in which the under-5 mortality rate was lower than the median under-5 mortality rate for 2018, were considered low child mortality settings. hCFR=in-hospital case-fatality ratio. ALRI=acute lower respiratory tract infection. LMICs=lower-middle-income countries. UMICs=upper middle-income countries. HICs=high-income countries. NA=not available.
Global estimates by age strata are the sum of estimates by child mortality settings; global estimates for children aged 0–59 months are the sum of estimates by age and child mortality settings.
Estimates derived from the meta–analysis.
No human metapneumovirus-associated ALRI deaths were reported in any of the studies from upper middle-income countries; thus hCFR for the strata was not estimated.
Estimates for the 0–59 month age group are the sum of estimates for the three age groups (0–5 months, 6–11 months, and 12–59 months).