Table 4.

Estimates of global human metapneumovirus-attributable ALRI cases, hospital admissions, and mortality, projected using attributable fractions that were calculated by use of inflation factors

	Attributable fraction, %*	Global human metapneumovirus-associated burden estimates	Global human metapneumovirus-attributable burden estimates†
Human metapneumovirus-attributable ALRI cases (millions)	78%‡	14·2 (10·2–20·1)	11·1 (8·0–15·7)
Human metapneumovirus-attributable ALRI hospital admissions (thousands)	78%	643 (425–977)	502 (332–762)
Human metapneumovirus-attributable ALRI deaths	70%§	16 100 (5700–88 000)	11 300 (UR 4000–61 600)

Data in parentheses are uncertainty ranges. ALRI=acute lower respiratory tract infection.

^*The proportion of human metapneumovirus-positive cases and deaths attributable to human metapneumovirus.

^†Applying the corresponding attributable fraction to the estimates of human metapneumovirus-associated burden.

^‡The attributable fraction for human metapneumovirus-associated ALRI cases was calculated using odds ratios from a systematic review and two multi-country studies; the median odds ratio from the three studies was input to yield the attributable fraction for human metapneumovirus-ALRI cases (78%); all references are in the appendix (p 18).

^§The attributable fraction for human metapneumovirus-associated ALRI deaths was modelled using the attributable fraction for human metapneumovirus cases and the ratio of case-fatality between human metapneumovirus-attributable cases and human metapneumovirus-associated cases (appendix pp 17–18).