Figure 2.

Time-dependent manners of triptolide-induced liver injury. Mice were treated with 0.8 mg/kg of triptolide and sacrificed at 0, 12, 24, 48 h, respectively. (A) ALT and AST levels in serum. (B) Micrographs of H&E stained liver sections (200×). Black arrows indicated apoptosis and black arrowheads indicated necrosis. The data were expressed as mean ± SEM (n=8). Statistical analyses were performed with Student’s t tests. **p<0.01.