Table 1.
Characteristics of familial IgA nephropathy and sporadic IgA nephropathy patients at time of diagnosis
| Parameters | Familial IgAN (n = 348) | Sporadic IgAN (n = 1116) | P value |
|---|---|---|---|
| Male sex | 175 (50) | 593 (53) | 0.35 |
| Age at disease onset, yr, mean ± SD | 35 ± 15 | 37 ± 12 | 0.03 |
| Early-onset patients | 137 (40) | 358 (32) | 0.003 |
| Proteinuria, g/24 h, median (range) | 0.55 (0.03–4.14) | 1.46 (0.02–19.48) | <0.001 |
| Steroids and/or immunosuppressants | 67 (19) | 608 (54) | <0.001 |
| Severity of disease at diagnosis | 0.32 | ||
| Preserved eGFR | 201 (58) | 612 (55) | |
| Nonpreserved eGFR | 147 (42) | 504 (45) | |
| Oxford MEST-C | n = 166 | n = 713 | |
| M1 | 38 (23) | 257 (36) | 0.002 |
| E1 | 31 (19) | 236 (33) | <0.001 |
| S1 | 113 (68) | 571 (80) | 0.001 |
| T1/2 | 41 (25) | 323 (45) | <0.001 |
| C1/2 | 73 (44) | 348 (49) | 0.31 |
eGFR, estimated glomerular filtration rate; IgAN, IgA nephropathy.
Values are n (%), unless otherwise noted.
Early-onset were patients with disease onset at age <30 years. Late-onset were patients with disease onset at age ≥30 years. Proteinuria at disease onset was presented with median (range) and transformed by log when compared in the 2 groups. Preserved eGFR group: patients with eGFR ≥60 ml/min per 1.73 m2. Nonpreserved eGFR group: patients with eGFR <60 ml/min per 1.73 m2.
Oxford MEST-C score: M, mesangial hypercellularity; E, presence of endocapillary proliferation; S, segmental glomerulosclerosis/adhesion; T, severity of tubular atrophy/interstitial fibrosis; C, presence of crescent.
Tests with P <0.05 are indicated in bold.