. 2021 Jan 4;78(4):1–12. doi: 10.1001/jamaneurol.2020.4920

Table 3. Estimated Marginal Means of Magnetic Resonance Imaging Features of Cognitive Phenotypes.

Variable	Mean (SE), mL		P value vs HC^a	Mild–verbal memory/semantic fluency, mean (SE), mL	P value^a		Mild–multidomain, mean (SE), mL	P value^a		Severe–executive/attention, mean (SE), mL	P value^a		Severe–multidomain, mean (SE), mL	P value^a
Variable	HC	PC	P value vs HC^a	Mild–verbal memory/semantic fluency, mean (SE), mL	vs HC	vs PC	Mild–multidomain, mean (SE), mL	vs HC	vs PC	Severe–executive/attention, mean (SE), mL	vs HC	vs PC	Severe–multidomain, mean (SE), mL	vs HC	vs PC
No.	50	39	NA	49	NA	NA	37	NA		22	NA	NA	24	NA	NA
T2 LV	NA	51.33 (31.15)	NA	75.99 (30.49)	NA	.23	76.29 (31.56)	NA	.15	99.69 (34.07)	NA	.04	133.70 (33.56)	NA	<.001
NBV	1532.61 (31.39)	1502.55 (31.27)	.13	1493.63 (30.85)	.03	.63	1469.94 (31.52)	.001	.11	1479.23 (33.10)	.03	.31	1423.67 (32.77)	<.001	.001
NGMV	764.07 (39.02)	749.69 (39.00)	.25	733.70 (38.86)	.01	.18	715.71 (39.08)	.002	.04	725.78 (39.63)	.01	.12	703.70 (39.51)	<.001	.002
NCGMV	698.93 (35.42)	687.69 (35.40)	.36	672.04 (35.26)	.02	.19	662.59 (35.48)	.005	.04	665.35 (36.01)	.02	.13	646.36 (35.89)	<.001	.005
NWMV	765.72 (68.22)	752.90 (68.22)	.39	759.16 (68.15)	.59	.59	743.06 (68.25)	.06	.51	753.64 (68.51)	.51	.94	718.99 (68.45)	<.001	.02
NThalV	10.39 (0.28)	9.69 (0.28)	.005	9.62 (0.27)	.001	.78	9.31 (0.28)	<.001	.13	9.35 (0.31)	.001	.22	8.72 (0.30)	<.001	.001
NCaudV	5.39 (0.81)	5.14 (0.81)	.15	5.17 (0.81)	.15	.95	5.06 (0.81)	.05	.65	5.16 (0.81)	.24	.95	4.87 (0.81)	.004	.15
NPutaV	6.39 (0.25)	6.08 (0.25)	.09	6.00 (0.25)	.03	.70	5.95 (0.25)	.01	.54	5.94 (0.27)	.04	.54	5.68 (0.26)	<.001	.05
NPallV	2.23 (0.08)	2.23 (0.08)	.97	2.27 (0.08)	.78	.78	2.20 (0.08)	.78	.78	2.17 (0.09)	.78	.78	2.05 (0.09)	.17	.17
NAmygV	1.84 (0.10)	1.74 (0.10)	.33	1.82 (0.09)	.96	.41	1.82 (0.10)	.96	.41	1.82 (0.10)	.96	.43	1.69 (0.10)	.27	.73
NAccuV	0.74 (0.16)	0.69 (0.16)	.22	0.66 (0.16)	.04	.54	0.67 (0.16)	.10	.82	0.67 (0.17)	.17	.83	0.55 (0.16)	<.001	.009
NHippV	5.58 (0.68)	5.42 (0.68)	.25	5.13 (0.68)	.03	.02	5.32 (0.68)	.06	.51	5.10 (0.69)	.006	.06	5.09 (0.69)	.002	.05

Abbreviations: HC, healthy control individuals; LV, lesion volume; NA, not applicable; NAccuV, normalized accumbens volume; NAmygV, normalized amygdala volume; NBV, normalized brain volume; NCaudV, normalized caudate volume; NCGMV, normalized cortical gray matter volume; NGMV, normalized gray matter volume; NHippV, normalized hippocampal volume; NPallV, normalized pallidum volume; NPutaV, normalized putamen volume; NThalV, normalized thalamic volume; NWMV, normalized white matter volume; PC, patients with preserved cognition.

^{^a}

P values were adjusted for multiple comparisons (Bonferroni method).