Table 2.

Transgenic platforms for the humanized immune mouse model

Name	Transgenic molecules	Advantages	Limitations	Reference
NBSGW	c-Kit	Without irradiation; development of erythropoiesis and platelet	Not reported	[56]
NSG-SGM3	SCF, GM-CSF, IL-3	Stable HSCs engraftment; increased monocytes, macrophages and DCs	Impaired stem cell function; short-term reconstitution	[72]
NOG-EXL	GM-CSF, IL-3	Stable HSCs engraftment; increased monocytes, macrophages and DCs	Increased anemia	[73]
MISTRG	GM-CSF, IL-3, M-CSF, TPO, SIRPα	Stable HSCs engraftment; increased monocytes, macrophages and DCs; improved NK cells development	Increased anemia; shorter lifespan	[62]
NOG-dKO	β2mnull, IAβnull	Decreased GVHD	Less T-cell differentiation	[37]
NSG-HLA	HLA class I and II	HLA-restricted B- and T-cell functions; antigen-specific IgG responses	Pre-selection of HLA in donor cells	[74,75]