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. 2020 Dec 1;10(12):4251–4265.

Figure 1.

Figure 1

The biological characterization of the gefitinib resistant lung adenocarcinoma cells (PC9/GR). A. The epithelial morphology of lung adenocarcinoma cells (PC9). B. The mesenchymal morphology of the gefitinib resistant lung adenocarcinoma cells (PC9/GR). C. The sensitivities of PC9 and PC9/GR cells to gefitinib. D. The sensitivities of PC9 and PC9/GR cells to cisplatin. E. The sensitivities of PC9 and PC9/GR cells to docetaxel. F. The histogram shows the PC9 and PC9/GR cells generated colony numbers. G. Western blot analysis of the stemness related protein expressions of ALDH1A1, Oct4, Sox2 and ABCG2 in PC9 and PC9/GR cells. H. The histogram shows the significant increase of stemness protein expressions in PC9/GR cells, compared to the parent PC9 cells. I. The PC9 cells penetrated transwell membrane. J. The PC9/GR cells penetrated transwell membrane. K. The histogram shows the penetrated cell number of PC9 and PC9/GR cells. L. Western blot analysis of the EMT related protein expressions of vimentin, N-cadherin, Slug and E-cadherin in PC9 and PC9/GR cells. M. Histogram shows the significant increase of vimentin, N-cadherin, Slug protein expressions and decrease of E-cadherin in PC9/GR cells, compared to the parent PC9 cells. *P<0.05, **P<0.01.