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. 2020 Dec 1;10(12):4251–4265.

Figure 4.

Figure 4

c-kit inhibitors (imatinib and anlotinib) inhibited the growth of PC9/GR cells and their mechanisms of action. A. Imatinib inhibited the growth of the parent PC9, the control PC9/GR and PC9/GR-shc-kit cells in vitro (*, PC9/GRvs. PC9/GR; #, PC9/GR-shc-kit vs. PC9/GR). B. The histogram shows the imatinib treated PC9/GR cells generated colony numbers. C. Anlotinib inhibited the growth of the parent PC9, the control PC9/GR and PC9/GR-shc-kit cells in vitro (*, PC9/GRvs. PC9/GR; #, PC9/GR-shc-kit vs. PC9/GR). D. The histogram shows the anlotinib treated PC9/GR cells generated colony numbers. E. Western blot analysis of the stemness related protein expressions of ALDH1A1, Oct4, Sox2 and ABCG2 in imatinib and anlotinib treated PC9/GR cells. F. The histogram shows the significant decrease of stemness protein expressions in imatinib and anlotinib treated PC9/GR cells, compared to the control PC9/GR cells.