Table 2.
Patient characteristics according to the expression of exoPD-L1 and sPD-L1
| Characteristics | ENKTL, nasal type | ENKTL, nasal type | ||||||
|---|---|---|---|---|---|---|---|---|
|
|
|
|||||||
| Total | High exoPD-L1 group | Low exoPD-L1 group | P-Value | Total | High sPD-L1 group | Low sPD-L1 group | P-value | |
| Patient number | 99 | 11 | 88 | 96 | 21 | 75 | ||
| Gender | 0.696 | 0.183 | ||||||
| Male | 78 | 8 (10.3) | 70 (89.7) | 73 | 18 (24.7) | 55 (75.3) | ||
| Female | 21 | 3 (14.3) | 18 (85.7) | 23 | 3 (13.0) | 20 (87.0) | ||
| Age (years) | 1.000 | 0.163 | ||||||
| > 60 | 11 | 1 (9.1) | 10 (90.9) | 7 | 3 (42.9) | 4 (57.1) | ||
| ≤ 60 | 88 | 10 (11.4) | 78 (88.6) | 89 | 18 (20.2) | 71 (79.8) | ||
| Stage | 0.516 | 0.006 | ||||||
| I-II | 93 | 10 (10.8) | 83 (89.2) | 90 | 17 (18.9) | 73 (81.1) | ||
| III-IV | 6 | 1 (16.7) | 5 (83.7) | 6 | 4 (66.7) | 2 (33.3) | ||
| B symptoms | 0.749 | 0.006 | ||||||
| Yes | 54 | 7 (13.0) | 47 (87.0) | 50 | 16 (32.0) | 34 (68.0) | ||
| No | 45 | 4 (8.9) | 41 (91.1) | 46 | 5 (10.9) | 41 (89.1) | ||
| LDH level | 1.000 | < 0.001 | ||||||
| Elevated | 16 | 1 (6.3) | 15 (93.7) | 14 | 10 (71.4) | 4 (28.6) | ||
| Normal | 93 | 10 (10.8) | 83 (89.2) | 82 | 11 (13.4) | 71 (86.6) | ||
| IPI | 0.306 | < 0.001 | ||||||
| 0-1 | 89 | 9 (10.1) | 80 (89.9) | 87 | 14 (16.1) | 73 (83.9) | ||
| ≥ 2 | 10 | 2 (20) | 8 (80) | 9 | 7 (77.8) | 2 (22.2) | ||
| PINK | 1.000 | 0.005 | ||||||
| 0-1 | 88 | 10 (11.4) | 78 (88.6) | 85 | 15 (17.6) | 70 (82.4) | ||
| ≥ 2 | 11 | 1 (9.1) | 10 (90.9) | 11 | 6 (54.5) | 5 (45.5) | ||
| SUVmax | 48 | 5 | 43 | 0.005 | 46 | 9 (19.6) | 37 (80.4%) | 0.024 |
| ≥ 15.4 | 10 | 4 (40.0%) | 6 (60.0%) | 9 | 5 (55.6%) | 4 (44.4%) | ||
| < 15.4 | 38 | 1 (2.6%) | 37 (97.4%) | 37 | 4 (10.8%) | 33 (89.2%) | ||
| Disease progression | 31.3% | 63.6% | 27.3% | 0.033 | 33.3% | 47.6% | 29.3% | 0.126 |
LDH, lactate dehydrogenase; IPI, International Prognostic Index; PINK, Prognostic Index of Natural Killer Lymphoma.