Table 2.
LncRNAs and circRNAs involved in glucose metabolism in HCC
| Glucose metabolism | LncRNA/circRNA | Effect | Target | Mechanism | Signaling pathway | Reference |
|---|---|---|---|---|---|---|
| glycolysis | linc01554 | Decrease | - | Promote PKM2 ubiquitination | Inactive Akt/mTOR | [42] |
| lncRNA Ftx | Increase | - | Promote GLUT | active PPARγ | [85] | |
| lncRNA WFDC21P | Decrease | - | Suppress PFKP and PKM2 transcription | - | [86] | |
| linc-RoR | Decrease | miR-145 | Inhibit HIF-1α and PDK1 expression | - | [54] | |
| lncRNAIDH1-AS1 | Decrease | - | Inhibit HIF-1α expression | - | [89] | |
| lncRNA RAET1K | Increase | miR-100-5p | Increase LDHA expression | - | [47] | |
| gluconeogenesis | MALAT1 | Decrease | - | Enhance TCF7L2 translation | Active Wnt and mTOR pathway | [90] |
| glycolysis | circMAT2B | Increase | - | Promote PKM2 expression | - | [39] |
| gluconeogenesis | circC3P1 | Increase | miR-4641 | Promote PCK1 expression | - | [69] |
“-”: unknown. Abbreviations: HCC: Hepatocellular carcinoma; PKM2: Pyruvate kinase M2; HIFs: Hypoxia-inducible factors; GLUT: Glucose transporters; PPARγ: Peroxisome proliferator-activated receptor γ; PFKP: the platelet isoform of phosphofructokinase; PDK1: Pyruvate dehydrogenase kinase; LDHA: Lactate dehydrogenase A; MALAT1: Metastasis-associated lung adenocarcinoma transcript 1; TCF7L2: Transcription factor 7 like 2.