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. 2020 Dec 29;34:2058738420958949. doi: 10.1177/2058738420958949

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© The Author(s) 2020

This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access page (https://us.sagepub.com/en-us/nam/open-access-at-sage).

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Figure 4. — SCFAs induce NET formation through FFA2R and NADPH oxidase complex. The competitive inhibitor of FFA2R, CATPB, caused the inhibition of NET by acetic acid (*P < 0.05) (a). Under similar conditions of stimuli, the inhibitor of G protein, genistein, led to a diminution of NET formation (*P < 0.05) (b), and the inhibitor of NADPH oxidase complex, DPI, showed a decrease on NET production (*P < 0.05) (c). It was reported in Relative Fluorescence Units (RFU). Each bar represents the mean ± SD of three independent experiments in duplicate, and was analyzed using the Mann-Whitney U test.