Table 1.

Baseline characteristics of study participants with diagnosed diabetes, according to history of severe hypoglycemia at baseline: the ARIC study (2011–2013)

	No prior episodes of severe hypoglycemia	Prior episode of severe hypoglycemia	P
N (%)	2,114 (96.4)	79 (3.6)
Age, years	75.8 (5.2)	77.1 (5.5)	0.035
Female sex, N (%)	1,206 (57.0)	50 (63.3)	0.27
Race, N (%)			<0.001
Whites	1,450 (68.6)	38 (48.1)
Blacks	664 (31.4)	41 (51.9)
Systolic blood pressure, mmHg	131.0 (19.6)	133.2 (20.3)	0.35
Diastolic blood pressure, mmHg	65.4 (10.9)	62.2 (11.1)	0.014
Hypertension, N (%)	1,781 (85.7)	67 (89.3)	0.37
Current cigarette smoking, N (%)	115 (6.4)	1 (1.8)	0.36
Current alcohol use, N (%)	756 (38.8)	15 (22.4)	0.019
BMI, kg/m2	30.6 (6.1)	31.0 (7.4)	0.63
eGFR, mL/min per 1.73 m2	67.5 (19.2)	54.5 (23.3)	<0.001
eGFR <60 mL/min per 1.73 m2, N (%)	717 (34.6)	38 (52.1)	0.002
HDL cholesterol, mg/dL	48.2 (12.5)	48.0 (12.8)	0.86
LDL cholesterol, mg/dL	93.8 (34.2)	96.6 (36.1)	0.49
Lipid-lowering medications, N (%)	1,477 (70.4)	58 (73.4)	0.56
Diabetes medications, N (%)			<0.001
No medication use	946 (45.0)	13 (16.5)
Any insulin use	309 (14.7)	44 (55.7)
Oral medications only	848 (40.3)	22 (27.8)
HbA1c, %	6.6 (1.1)	7.1 (1.1)	<0.001
Diabetes duration, years	10.0 (6.6)	18.3 (6.1)	<0.001
Prevalent CVD, N (%)	711 (33.6)	46 (58.2)	<0.001
hs-cTnT, ng/L	17.0 (23.0)	32.7 (41.3)	<0.001
NT-proBNP, pg/mL	135.4 (66.5–306.3)	346.7 (145.3–1,236)	<0.001
C-reactive protein, mg/L	5.0 (9.4)	4.6 (4.8)	0.71
ALT, units/L	20.2 (18.6)	17.3 (11.7)	0.18
AST, units/L	22.9 (13.1)	22.2 (9.4)	0.65
ACE inhibitors, N (%)	917 (43.4)	41 (51.9)	0.13
ARBs, N (%)	249 (11.8)	6 (7.6)	0.25

Data are mean (SD) or median (range) unless otherwise indicated.