Figure 2.

Effects of interventions in ACCORD on CAN. The primary model was adjusted by fixed effects including trial assignments, seven clinical center networks, time after randomization, prior CVD events, and baseline CAN status. The full model was adjusted by additional baseline characteristics as fixed effects, namely, age, sex, diabetes duration, HbA_1c, BMI, height, alcohol, cigarettes, SBP and DBP, LDL cholesterol, triglycerides, HDL cholesterol, UACR, and use of thiazolidinediones, insulin, β-blockers, ACEIs/ARB, and statins. Both models included participants as random effects.