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. 2021 Jan 5;40:6. doi: 10.1186/s13046-020-01791-9

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 4 — CircLMO7 promotes the expression of WNT2. a. Pattern diagram showing the downstream target gene of miR-30a-3p predicted by TargetScan7.2 and miRWalk3. b. Western blotting showed that the expression levels of miR-30a-3p and WNT2 were negatively correlated. c. Sequence map of the binding site between miR-30a-3p and WNT2. d. A luciferase reporter assay demonstrated that miR-30a-3p and WNT2 bind to each other. e. The KmPlot database showed that patients with lower WNT2 had better overall survival rates and disease-free survival rates than patients with higher WNT2. f. Immunohistochemistry showed that WNT2 was highly expressed in GC tissues; scale bar = 100 μm. g. The TCGA database showed that the expression of WNT2 in GC tissues was significantly higher than that in normal tissues. h. qRT-PCR showed that WNT2 was highly expressed in GC tissues. i. qRT-PCR showed that the expression levels of circLMO7 and WNT2 were positively correlated. j. Overexpression of circLMO7 promoted the expression of WNT2, while knockdown of circLMO7 inhibited the expression of WNT2; scale bar = 50 μm. All data are presented as the mean ± SD * P < 0.05, ** P < 0.01, *** P < 0.001