Fig. 10.

CLR01 treatment reduces microglia density in the CA3 region of P301S-tau mice. Brain sections from P301S-tau mice and wild-type littermates were stained using an anti-Iba-1 antibody and visualized by immunofluorescence. a–e Representative images of the CA3 area of wild-type (WT) mice treated with 0 (a) or 1.0 (b) mg/kg CLR01 and transgenic (Tg) P301S-tau mice treated with 0 (c), 0.3 (d), or 1.0 (e) mg/kg per day CLR01. f The data were quantified as the percentage of Iba-1-positive area in the CA3 and are presented as mean ± SD. P values were calculated using a one-way ANOVA with post hoc Tukey test