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. 2021 Jan 4;19:7. doi: 10.1186/s12957-020-02107-z

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 2 — Volcano plots of a DEMs in GSE72199, b DEMs in GSE54088, and c DEGs in GSE81582 (GPL15207). The red color represents the upregulated genes between primary CRC tumors and liver metastases, while the blue color represents the downregulated genes, and the black indicates no significant difference. The Venn diagram shows the common d upregulated DEMs and e downregulated DEMs between GSE72199 and GSE54088. Blue represents the number of DEMs in GSE72199, yellow represents the number of DEMs in GSE54088, and the intersecting part represents the DEMs common to both data sets