Table 1.
Characteristics of 34 included studies in this meta-analysis
| First author | Location | Typing method | Year of publication | Genotypes | Total of genotypes | MDR genotypes | Sample size | STROBE Score | Type of sample | Nationality |
|---|---|---|---|---|---|---|---|---|---|---|
| Amirmozafari [17] | Tehran | Spoligo | 2006 | CAS- EAI-Beijing-T- Haarlem-MANU | CAS:19- EAI:31-Beijing:14-T:39- Haarlem:75-MANU:3-LAM:1-West African:1 | – | 439 | 23 | PTB-EPTB | Iranian - Afghan immigrants |
| Ramazanzadeh [18] | Tehran | Spoligo | 2006 | CAS- EAI-Beijing -T- Haarlem-WestAfrican - LAM | CAS:7- EAI:27-Beijing:12-T:36- Haarlem:65-WestAfrican:1- LAM:1 | – | 346 | 26 | PTB-EPTB | Iranian |
| Ramazanzadeh [18] | Tehran | Spoligo | 2006 | CAS- EAI-Beijing -T- Haarlem | CAS:1- EAI:4-Beijing: 5-T:6- Haarlem:20 | – | 93 | 27 | PTB-EPTB | Afghan immigrants |
| Masjedi [19] | Tehran | IS6110-RFLP /Spoligo | 2008 | CAS- EAI-Beijing-T- Haarlem-X | CAS:38-EAI:71-Beijing:8-T:44-Haarlem:14-X:1 | Beijing:2-Haarlem:3 | 199 | 26 | PTB-EPTB | Iranian |
| Masjedi [19] | Tehran | IS6110-RFLP /Spoligo | 2008 | CAS- EAI-Beijing-T- Haarlem-X | CAS:12-EAI:19-Beijing:4-T:3-Haarlem:6-X:11 | Beijing:1-T:1-Haarlem:5 | 59 | 24 | PTB-EPTB | Afghan immigrants |
| Tajeddin [20] | Tehran | Spoligo | 2009 | CAS- EAI-Beijing-T- Haarlem-U | CAS:118-EAI:64-Beijing:15-T:16-Haarlem:13-U:12 | CAS:7-EAI:8-Beijing:6-T:2- U:2-HaarlemI:3 | 238 | 28 | PTB | Iranian |
| Ramazanzadeh [21] | Tehran | Spoligo | 2009 | CAS-Beijing-T-Haarlem- MANU-EAI-LAM-West African | CAS:18-Beijing:14-T:39-Haarlem:75-MANU:4- EAI:31-LAM:1-West African:1 | – | 523 | 30 | PTB-EPTB | Iranian - Afghan immigrants |
| Rohani [22] | Mashhad | Spoligo | 2009 | CAS-NEW1-Beijing-T-Haarlem- MANU-URAL-EASTMED | CAS:6-NEW1:2-Beijing:8-T:2-Haarlem:1-MANU:14-URAL:1-EASTMED:3 | Beijing:3 | 113 | 25 | PTB | Iranian - Afghan immigrants |
| Ahmadi [23] | Tehran | Spoligo | 2009 | CAS- EAI-Beijing-T- Haarlem-U-Bovis | CAS:55- EAI:39-Beijing:6-T:16- Haarlem:52-U:9-Bovis:2 | – | 179 | 24 | PTB | Iranian |
| Ahmadi [23] | Tehran | Spoligo | 2009 | CAS- EAI-Beijing- Haarlem-U | CAS:19- EAI:16-Beijing:7- Haarlem:14-U:3 | – | 59 | 22 | PTB | Afghan immigrants |
| Jafarian [24] | Tehran | 12 loci MIRU-VNTR /Spoligo | 2010 | CAS- NEW1-Haarlem-LAM-Uganda | CAS:8- NEW1:6-Haarlem:7-LAM:2-Uganda:2 | 0 | 30 | 24 | PTB | Iranian |
| Merza [25] | Tehran | Spoligo | 2010 | CAS- Beijing- EAI- Haarlem-T- X | CAS:169- Beijing: 11- EAI:212- Haarlem:41, T:324-X:16 | – | 981 | 30 | PTB | Iranian |
| Merza [25] | Tehran | Spoligo | 2010 | CAS- Beijing- EAI- Haarlem-T- X | CAS:176- Beijing: 76- EAI:174- Haarlem:31, T:67-X:10 | – | 634 | 30 | PTB | Afghan immigrants |
| Merza [25] | Tehran | Spoligo | 2010 | CAS- Beijing- EAI- Haarlem-T- X | CAS:12- Beijing: 1- EAI:15- Haarlem:3- T:23-X:2 | – | 93 | 22 | EPTB | Iranian |
| Merza [25] | Tehran | Spoligo | 2010 | CAS- Beijing- EAI- Haarlem-T- X | CAS:7- Beijing: 4- EAI:5- Haarlem:2- T:3-X:1 | – | 34 | 23 | EPTB | Afghan immigrants |
| Asgharzadeh [26] | Azarbaijan | IS6110-RFLP /12 loci MIRU-VNTR | 2011 | NEW1-Haarlem-S-Uganda-X- Cameroon-Bovis | NEW1:1-Haarlem:1-S:13-Uganda:1-X:1-Cameroon:1-Bovis:15 | – | 154 | 26 | PTB-EPTB | Iranian |
| Jafarian [27] | Tehran | 12 loci MIRU-VNTR | 2011 | CAS- NEW1-Beijing-Haarlem-EAI-LAM-Uganda-H37Rv-Bovis | CAS:49- NEW1:16- Beijing:14-Haarlem:3-EAI:1-LAM:14-Uganda:28-H37Rv:5-Bovis:10 | – | 140 | 26 | PTB | Iranian - Afghan immigrants |
| Zaker Bostanabad [28] | Tehran | Spoligo | 2011 | CAS- Beijing- EAI- Haarlem-T- U | CAS:18- Beijing: 38- U:8-EAI:34- Haarlem:41- T:10 | CAS:2-Beijing:1-EAI:3-U:1 | 149 | 25 | PTB | Iranian |
| Mozafari [29] | Tehran | 12/15 loci MIRU-VNTR /Spoligo | 2012 | CAS-NEW1-Beijing-Haarlem-LAM-URAL-Uganda-X-S-Camroon-Bovis | CAS:22-NEW1:25-Beijing:20-Haarlem:2- LAM:5-URAL:3-Uganda:9-X:1-S:2-Cameroon:1-Bovis:1 | Beijing:7 | 105 | 27 | PTB | Iranian |
| Haeili [30] |
5 provinces |
Spoligo | 2013 | CAS- NEW1- Beijing- Haarlem-T-MANU-LAM-EAI-U-H37Rv | CAS:70-NEW1:100-Beijing: 3-T:53-Haarlem:3- MANU:22-LAM:18-EAI:4-U:3-H37Rv:2 | CAS:1- NEW1:5-Beijing: 3 | 291 | 29 | PTB-EPTB | Iranian |
| Torkaman [31] | Tehran | 15 loci MIRU-VNTR /Spoligo | 2014 | CAS-NEW1-Beijing-Haarlem-URAL-T-MANU-Bovis | CAS:15-NEW1:14-Beijing:6-Haarlem:3- T:6-MANU:8-URAL:2-Bovis:3 | – | 73 | 26 | PTB | Iranian |
| Torkaman [31] | Tehran | 15 loci MIRU-VNTR /Spoligo | 2014 | CAS-NEW1-Beijing-Haarlem | CAS:7-NEW1:7-Beijing:5-Haarlem:1 | – | 29 | 24 | PTB | Afghan immigrants |
| Velayati [32] |
21 provinces |
Spoligo | 2014 | CAS-Beijing- Haarlem-T-MANU-LAM-EAI-U-X- Bovis | CAS:471-EAI:3-Beijing: 101-T:195-Haarlem:326- MANU:25-LAM:15-U:17-Bovis:10-X:2 | – | 1242 | 31 | PTB | Iranian- immigrants |
| Varahram [33] | Tehran | Spoligo | 2014 | CAS-Beijing- Haarlem-T-MANU-LAM-EAI-U | CAS:23-EAI:42-Beijing: 14-T:11-Haarlem:31- MANU:9-LAM:3-U:7 | CAS:1- T:1-EAI:5-Beijing:10- Haarlem:2- MANU:2-LAM:1-U:1 | 151 | 27 | PTB | Iranian - Afghan immigrants |
| Sharifpour [34] | Tehran | Spoligo | 2014 | CAS-Beijing- Haarlem-T | CAS:37-Beijing:11-Haarlem:72-T:18 | CAS:3-T:3-Beijing:4- Haarlem:3 | 190 | 25 | PTB | Iranian |
| Haeili [35] | IRAN | Spoligo | 2015 | CAS-NEW1-T-MANU-LAM | CAS:60-NEW1:86- T:46- MANU:19-LAM:15 | – | 251 | 25 | PTB | Iranian |
| Sharifpour [36] | Tehran | RD Typing/Spoligo | 2016 | CAS-Beijing- Haarlem-T | CAS:54-Beijing:28- Haarlem:85-T:27 | – | 250 | 26 | PTB | Iranian |
| Feyisa [37] | Tehran | IS6110-RFLP /Spoligo | 2016 | CAS- NEW1- Beijing-Haarlem-T-EAI-MANU-LAM-H37Rv | CAS:18- NEW1:15- Beijing:1-Haarlem:1-T:7- EAI:4-MANU:3-LAM:1- H37Rv:1 | – | 60 | 22 | PTB | Iranian |
| Feyisa [37] | Tehran | IS6110-RFLP /Spoligo | 2016 | NEW1-T-EAI | NEW1:7-T:2- EAI:1 | – | 10 | 20 | PTB | Afghan immigrants |
| Zamani [38] | Hormozgan | 15loci MIRU-VNTR/Spoligo | 2016 | CAS-Beijing-NEW1-T-Haarlem-LAM-MANU-EAI | CAS:7-Beijing:1-NEW1:2- Haarlem:1-LAM:9- MANU:3-EAI:1-T:5 | T:2-MANU:1 | 38 | 25 | PTB | Iranian |
| Riyahi Zaniani [39] | Isfahan | 15loci MIRU-VNTR | 2017 | CAS- NEW1- Beijing-URAL- LAM-S-X-EAI | CAS:10- NEW1:9- Beijing: 9-URAL:2- LAM:3-S:3-X: 1-EAI:1 | – | 38 | 24 | PTB | Iranian |
| Riyahi Zaniani [39] | Isfahan | 15loci MIRU-VNTR | 2017 | CAS- NEW1- Beijing-URAL- LAM-S-X-EAI | CAS:4- NEW1:3- Beijing: 3- S:1 | – | 11 | 23 | PTB | Afghan immigrants |
| Ravansalar [40] | Khorasan | 12 loci MIRU-VNTR /Spoligo | 2017 | CAS- NEW1- Beijing-T-Haarlem-MANU-U | CAS:19-Beijing:9-T:3-Haarlem:67-MANU:1-U:5 | Beijing:2 | 140 | 25 | PTB | Iranian |
| Mansoori [41] | Golestan | 24 loci MIRU-VNTR | 2018 | CAS- NEW1- Beijing-URAL- Haarlem-TUR | CAS:31-NEW1:45-Beijing:18-URAL:4-TUR:2-Haarlem:2 | 0 | 156 | 25 | PTB-EPTB | Iranian |
| Azimi [42] | Tehran | 15loci MIRU-VNTR | 2018 | CAS- NEW1 -WestAfrican - Bovis- H37Rv | CAS:1 -NEW1:18-WestAfrican:1 - Bovis: 1- H37Rv: 1 | – | 80 | 24 | PTB | Iranian |
| Kargarpour [43] | Tehran | Spoligo | 2018 | CAS-NEW1-T-MANU | CAS:2-NEW1:3-T:1-MANU:5 | – | 14 | 25 | PTB-EPTB | Iranian |
| Kochkaksaraei [44] | Golestan | 15loci MIRU-VNTR | 2019 | CAS- NEW1- Beijing-URAL-TUR-Cameroon | CAS:15-NEW1:36- Beijing:22-URAL:3-TUR:1-Cameroon:4 | 0 | 162 | 28 | PTB-EPTB | Iranian |
| Hadifar [45] | Tehran | 24 loci MIRU-VNTR /Spoligo | 2019 | CAS- NEW1- Beijing-URAL- T-Haarlem-EASTMED | CAS:25-NEW1:21-Beijing:10-URAL:4-T:17-Haarlem:2-EASTMED:4 | CAS:1-NEW1:1-Beijing:5-T:1 | 84 | 27 | PTB | Iranian |
| Hadifar [45] | Tehran | 24 loci MIRU-VNTR /Spoligo | 2019 | CAS- NEW1- Beijing-URAL- T-Haarlem-EASTMED | CAS:21-NEW1:28-Beijing:5-URAL:6-T:22-Haarlem:2-EASTMED:1-U:2 | CAS:1-NEW1:1 | 88 | 28 | EPTB | Iranian |
| Afaghi-Gharamaleki [46] | Tabriz | 15loci MIRU-VNTR | 2019 | CAS- NEW1 -Beijing-Uganda-LAM-TUR-Cameroon- Bovis- H37Rv | CAS:1- NEW1:30- Beijing:4-Uganda:18-LAM:1-TUR:2-Cameroon:1- Bovis:3- H37Rv:1 | – | 91 | 27 | PTB | Iranian |
| Hadifar [47] | Tehran | 24 loci MIRU-VNTR /Spoligo | 2019 | CAS- NEW1- Beijing | CAS:95-NEW1:80-Beijing:42 | – | 217 | 29 | PTB | Iranian |
| Vaziri [48] | Tehran | WGS | 2019 | CAS- NEW1- Beijing-URAL- T-TUR-H37Rv | CAS:7-NEW1:8-Beijing:14- URAL:2- T:4- TUR:1- H37Rv:1 | Beijing:14 | 38 | 25 | PTB | Iranian |
| Kargarpour [49] | Tehran | 24 loci MIRU-VNTR | 2019 | CAS- NEW1- Beijing- Haarlem-Uganda | CAS:5-NEW1:2-Beijing:2-Haarlem:1-Uganda:1 | – | 12 | 26 | PTB | Iranian |
| Kargarpour [50] | Tehran | 24 loci MIRU-VNTR | 2020 | CAS- NEW1- Beijing- Haarlem-Uganda | CAS:9-NEW1:4-Beijing:5-Haarlem:1-Uganda:1 | 0 | 45 | 28 | PTB | Iranian |
PTB Pulmonary Tuberculosis, EPTB Extrapulmonary Tuberculosis, WGS Whole-Genome Sequencing, MDR Multidrug resistant