Table 2.
Baseline characteristics according to dementia and mortality status at the end of the follow-up
| Sample characteristics | Dementia over follow-up | Mortality over follow-up | ||||
|---|---|---|---|---|---|---|
| No | Yes | p value | No | Yes | p value | |
| (n = 5251) | (n = 310) | (n = 4783) | (n = 778) | |||
| Age, years, mean (SD) | 55.2 (5.8) | 60.9 (5.0) | < 0.001 | 54.9 (5.7) | 59.6 (5.8) | < 0.001 |
| Women, n (%) | 1403 (26.7) | 105 (33.9) | 0.006 | 1289 (27.0) | 219 (28.2) | 0.49 |
| Married/cohabiting, n (%) | 4032 (76.8) | 224 (72.3) | 0.07 | 3697 (77.3) | 229 (71.9) | 0.001 |
| Education level, n (%) | ||||||
| Lower secondary school | 2209 (42.1) | 175 (56.5) | 2028 (42.4) | 356 (45.8) | ||
| Higher secondary school | 1459 (27.8) | 65 (21.0) | 1301 (27.2) | 223 (28.7) | ||
| University degree or higher | 1583 (30.2) | 70 (22.6) | < 0.001 | 1454 (30.4) | 199 (25.6) | 0.02 |
| Occupation, n (%) | ||||||
| Low | 493 (9.4) | 64 (20.7) | 449 (9.4) | 108 (13.9) | ||
| Intermediate | 2297 (43.7) | 121 (39.0) | 2085 (43.6) | 333 (42.8) | ||
| High | 2461 (46.9) | 125 (40.3) | < 0.001 | 2249 (47.0) | 337 (43.3) | < 0.001 |
| Cognitive function, mean (SD) | ||||||
| Reasoning | 48.8 (9.5) | 44.8 (11.1) | < 0.001 | 48.9 (9.5) | 46.4 (10.5) | < 0.001 |
| Memory | 7.1 (2.3) | 6.0 (2.2) | < 0.001 | 7.2 (2.3) | 6.4 (2.3) | < 0.001 |
| Phonemic fluency | 17.3 (4.3) | 15.8 (4.4) | < 0.001 | 17.4 (4.3) | 16.3 (4.2) | < 0.001 |
| Semantic fluency | 17.0 (4.0) | 15.2 (4.0) | < 0.001 | 17.1 (4.0) | 16.2 (4.2) | < 0.001 |
| Standardized global cognitive score | 0.0 (1.0) | − 0.5 (1.0) | < 0.001 | 0.0 (1.0) | − 0.3 (1.0) | < 0.001 |
| APOE genotype, n (%) | ||||||
| ε2ε2 | 33 (0.6) | 0 (0.0) | 28 (0.6) | 5 (0.6) | ||
| ε2ε3 | 664 (12.7) | 27 (8.7) | 593 (12.4) | 98 (12.6) | ||
| ε3ε3 | 3156 (60.1) | 140 (45.2) | 2856 (59.7) | 440 (56.6) | ||
| ε2ε4 | 131 (2.5) | 8 (2.6) | 117 (2.5) | 22 (2.8) | ||
| ε3ε4 | 1162 (22.1) | 111 (35.8) | 1082 (22.6) | 191 (24.6) | ||
| ε4ε4 | 105 (2.0) | 24 (7.7) | < 0.001 | 107 (2.2) | 22 (2.8) | 0.60 |