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. 2021 Jan 4;22:11. doi: 10.1186/s13059-020-02236-4

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 2 — In vivo nuclear mRNA structures are different from cytosolic mRNA structures across translation start and stop sites. a Comparison of average SHAPE reactivity profiles between nuclear and cytosolic mRNAs across the translation start codon. Average SHAPE reactivities downstream of the start codon are significantly higher in nuclear mRNAs compared to cytosolic mRNAs (Mann-Whitney test, the highest and lowest P values for the first ten nucleotides of the CDS region are shown). b Comparison of SHAPE reactivity profiles between nuclear and cytosolic mRNAs across the translation stop codon. Average SHAPE reactivities at the stop codon are significantly lower in nuclear mRNAs compared to cytosolic mRNAs (Mann-Whitney test, the P values were shown)