Fig. 2.

Histological profile of breast cancer in macaques. The morphology (Hematoxylin-Eosin stained; HE) and immunohistochemical staining for estrogen receptor (ER) alpha, progesterone receptor (PGR) and human epidermal growth factor receptor 2 (HER-2) are shown to indicate a Luminal A type (A1-A4), HER-2 positive (B1-B4), and triple-negative (C1-C4) breast cancer, which are similar to those in humans. Strong positive nuclear staining of ER alpha (A2) and PGR (A3) are shown in Luminal A type; HER-2 positive breast cancer shows cytoplasmic overexpression of HER-2 (B4); and ER, PGR and HER-2 are not expressed in triple-negative breast cancer (C2-C4). Bars = 100 μm