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. 2021 Jan 4;13:1. doi: 10.1186/s13073-020-00808-4

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 2 — Manhattan plot showing the APOE ε4 vs. ε2 carrier EWAS and DMR meta-analyses results. Each point represents one of the 772,453 loci included in the EWAS meta-analysis, with the point’s position being determined by genomic position (x-axis) and significance in the EWAS meta-analysis (−log₁₀ P value; y-axis). Sites attaining genome-wide significance (P ≤ 3.6 × 10⁻⁸) are indicated in red and those that are involved in a significant DMR (Bonferroni-correct P ≤ 0.05) are indicated in blue. The locations of DMRs are further indicated by vertical blue lines. The solid horizontal line is the threshold for genome-wide significance (P ≤ 3.6 × 10⁻⁸)