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. 2021 Jan 4;21:4. doi: 10.1186/s12879-020-05676-2

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 3 — Comparison of the performance of adenosine deaminase (ADA) and the T-SPOT assay in the pleural fluid (PF) stratified by age. a Comparison of median ADA levels between different age groups. b Comparison of median spot-forming cells (SFCs) in the PF T-SPOT assay between different age groups. For group comparison, the Kruskal-Wallis test was used. ns, not significant. *p < 0.05,**p < 0.01,***p < 0.005; & represents internationally recognized cut-off (40 IU/L), and # represents the cutoff (22.4 IU/L for ADA, 466 SFCs/10⁶ mononuclear cells for PF T-SPOT) derived from the receiver operating characteristic (ROC) curves. The green and orange lines represent the median PF Max SFCs in the TPE and non-TPE groups, respectively