Table 5.
Performance outcomes of a bioclinical score for ADA and T.SPOT
| Score (non: TPE) |
Assay (cut-off value a) |
Sensitivity | Specificity | PPV | NPV | Accuracy | §X2 | §P value | ¶X2 | ¶P value |
|---|---|---|---|---|---|---|---|---|---|---|
| ADA(40) | 23.5 | 96.9 | 80.0 | 70.5 | 71.4 | 5.82 | 0.016 | 0.80 | 0.370 | |
|
0 (32:17) |
PB T.SPOT(24) | 76.5 | 62.5 | 52.0 | 83.3 | 67.3 | ||||
| PF T.SPOT(466) | 76.5 | 84.4 | 72.2 | 87.1 | 81.6 | |||||
| 2 | ADA(40) | 51.0 | 94.4 | 92.9 | 57.1 | 68.7 | 21.42 | < 0.001 | 7.26 | 0.006 |
| PB T.SPOT(24) | 79.4 | 64.5 | 76.4 | 68.3 | 73.3 | |||||
|
/3/5 (107:155) |
PF T.SPOT(466) | 76.1 | 80.4 | 84.9 | 69.9 | 77.9 | ||||
| 6/8/9 | ADA(40) | 73.2 | 86.7 | 95.9 | 43.3 | 75.8 | 10.26 | 0.001 | 0.14 | 0.705 |
| (30:127) | PB T.SPOT(24) | 93.7 | 93.3 | 98.3 | 77.8 | 93.6 | ||||
| PF T.SPOT(466) | 89.8 | 90.0 | 97.4 | 67.5 | 89.8 | |||||
| ADA(40) | 81.6 | 80.0 | 98.8 | 18.2 | 81.6 | 0.04 | 0.840 | 0 | > 0.999 | |
|
11 (5:98) |
PB T.SPOT(24) | 85.7 | 60.0 | 97.7 | 17.6 | 84.5 | ||||
| PF T.SPOT(466) | 80.6 | 80.0 | 98.8 | 17.4 | 79.0 |
ADA adenosine deaminase, BMI body mass index, TPE tuberculous pleural effusion, NPV negative predictive value, PPV positive predictive value
Age < 45 yrs., male and BMI < 22 scored 6, 3, 2 points, respectively
§Comparisons were performed for sensitivity between ADA and PF T.SPOT using chi-square test
¶ Comparisons were performed for specificity between ADA and PF T.SPOT using chi-square test
a Values are expressed as IU/L for ADA, and as SFCs/106 mononuclear cells for T-SPOT.Data are presented as percentage